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The response of Staphylococcus aureus to metal ion stress
Reference
P09902
Principal Investigator / Supervisor
Professor Simon J. Foster
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
174,414
Status
Completed
Type
Research Grant
Start date
01/11/1998
End date
01/11/2001
Duration
36 months
Abstract
Staphylococcus aureus is a major human pathogen of increasing importance. The response to iron (and other metal ion) limitation is likely to be an essential part of the pathogenic process. Recently four putative metal regulatory elements (MREs) have been identified in S. aureus, which are likely to form complex interacting circuits controlling the response of the organism to metal ion availability flux. The project will take an integrated molecular biological, biochemical and physiological approach, to study the individual and combined roles of the MREs in cellular physiology and pathogenicity. This will establish the importance of the MREs and metal ion stress, in the life and pathogenicity of this medically important organism and lead to the possible design of novel control measures.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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