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Investigating novel xenobiotic-metabolising P450 in Phanerochaete chrysosporium a white-rot fungus used in bioremediation

Reference	P09637
Principal Investigator / Supervisor	Professor Steven Kelly
Co-Investigators / Co-Supervisors
Institution	Aberystwyth University
Department	Inst of Biological, Environ & Rural Sci
Funding type	Research
Value (£)	157,380
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	01/03/2002
Duration	41 months

Abstract

Phanerochaete chrysoporium is a white-rot fungus used commercially in bioremediation, where extracellular enzymes have mainly been associated with xenobiotic metabolism e.g. peroxidases, although some questions have arisen over their central role in the metabolism of all classes of pollutants. The intracellular cytochrome P450 system is a candidate system for involvement and has been shown to metabolise polycyclic aromatic hydrocarbons by both a microsomal system and a novel NADPH-dependant soluble fungal enzyme. This programme would undertake a molecular study of the cytochrome P450 systems of the endoplasmic reticulum and cytosol, characterising the proteins and genes responsible. This research will have both academic value for understanding P450 biodiversity and will assist an understanding of the biochemical processes underpinning bioremediation in this fungus.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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