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Isolation and functional analysis of Rar1 a disease resistance signalling gene in barley
Reference
P09491
Principal Investigator / Supervisor
Professor Sir David Baulcombe
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Sainsbury Laboratory
Funding type
Research
Value (£)
264,203
Status
Completed
Type
Research Grant
Start date
18/05/1998
End date
18/11/2001
Duration
42 months
Abstract
A disease resistance signalling gene in barley, Rar1, has been physically delimited on a YAC clone of 335 kb. It is required for the function of the majority of described race-specific resistance genes to the powdery mildew fungus, Erysiphe graminis f sp hordei, and represents a point of convergence in race-specific resistance reactions. We propose the map-based isolation of Rar1 by utilising chemically- induced mutants in the target gene. A novel transient transformation system in barley will be employed to initiate a functional analysis of Rar1 with respect to subcellular localisation, functional domains, and activation of host cell death. Suppressor mutants of Rar1 have been isolated which will be genetically characterised for their role in down regulating race-specific resistance reactions.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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