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Award details
Production of recombinant adhesive protein in plants
Reference
P09350
Principal Investigator / Supervisor
Professor Simon McQueen-Mason
Co-Investigators /
Co-Supervisors
Dr Jurgen Denecke
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
193,187
Status
Completed
Type
Research Grant
Start date
01/06/1998
End date
01/02/2002
Duration
44 months
Abstract
Mussel adhesive proteins form highly resistant strong bonds with an array of surfaces and can fix under water (a property not found in man-made glues). The fixed glue is neither cytotoxic nor antigenic. These properties have led to predictions of wide-ranging applications in engineering and medicine. The natural source of protein is too limited to allow exploitation. Attempts to produce recombinant adhesive proteins in microbes have failed due to problems in processing repetitive DNA and differences in codon use. A certain class of plant structural proteins are composed of a repetitive motif nearly identical to mussel adhesives. In addition, codon use between mussels and plants is similar. We plan to investigate the use of plants to produce recombinant adhesive proteins in order to provide the essential foundation for wide-ranging applications.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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