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The transport of capsular polysaccharides across the periplasmic space in Escherichia coli
Reference
P09300
Principal Investigator / Supervisor
Professor Ian Roberts
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
174,399
Status
Completed
Type
Research Grant
Start date
01/06/1998
End date
01/06/2001
Duration
36 months
Abstract
The proposed work will use multi-disciplinary approaches to elucidate at the molecular level the transport of group II capsular polysaccharides across the periplasmic space and onto the cell surface in Escherichia coli. The specific aims of the project are initially, to establish the role of membrane adhesion sites between the inner and outer membrane in the transport of capsular polysaccharides across the periplasmic space. Subsequently, the specific interactions between the proteins known to be involved in the transport process will be characterised. As a consequence of these studies it will be possible to understand at the molecular level the mechanisms by which these large negatively charged macromolecules are exported onto the bacterial cell surface.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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