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Award details
Development of an in vitro DNA packaging system from the Streptomyces phage oC31
Reference
P09260
Principal Investigator / Supervisor
Professor Margaret Smith
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
School of Molecular Medical Sciences
Funding type
Research
Value (£)
228,912
Status
Completed
Type
Research Grant
Start date
01/05/1998
End date
01/05/2001
Duration
36 months
Abstract
New tools for the genetic manipulation of Streptomyces must become available to identify and exploit secondary metabolites with novel activities. The aim of this project is primarily to develop an in vitro DNA packaging system for use with phi C31 cosmid vectors and to identify the host receptor with a view to increasing the host range. The mechanisms of phage morphogenesis, DNA packaging and lysis of the host cell will also be investigated, in particular where comparative analyses with well-studied systems will yield a deeper understanding of general mechanisms.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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