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Gametic imprinting in Arabidopsis
Reference
P08575
Principal Investigator / Supervisor
Professor Roderick Scott
Co-Investigators /
Co-Supervisors
Institution
University of Bath
Department
Biology and Biochemistry
Funding type
Research
Value (£)
140,801
Status
Completed
Type
Research Grant
Start date
29/06/1998
End date
29/06/2001
Duration
36 months
Abstract
Reciprocal crosses in Arabidopsis between diploid (2x) and autotetraploid (4x) parents reveal the operation of gametic imprinting within the endosperm. Deviations from the normal 2:1 ratio of maternal to paternal genomes in the endosperm reduce (maternal excess) or increase (paternal excess) the number of endosperm cells and the size of the mature seed. Maternal excess also slows the rate of embryogenesis. These parameters are easily measured and form the basis of an assay for the level of gametic imprinting. The assay will be used (i) to investigate the role of methylation in gametic imprinting by exploiting DNA hypomethylation mutants and the chemical demethylating agent, 5-azacytidine; and (ii) as the basis of a genetic screen for mutants affected in gametic imprinting.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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