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Structure function and regulation of plant sterol 14-demethylase
Reference
P08512
Principal Investigator / Supervisor
Professor Steven Kelly
Co-Investigators /
Co-Supervisors
Institution
Aberystwyth University
Department
Inst of Biological, Environ & Rural Sci
Funding type
Research
Value (£)
171,800
Status
Completed
Type
Research Grant
Start date
02/11/1998
End date
01/05/2002
Duration
42 months
Abstract
Plant sterol 14-demethylase was recently identified as a member of the cytochrome P45051 (CYP51) family on isolating the full-length cDNA from Sorghum and a shorter fragment of wheat. This is an ancient evolutionary role for the CYP enzymes, the only form found in animals, plants and fungi. cDNAs from Sorghum and wheat would be purified after heterologous expression, characterised for substrate and inhibitor selectivity and subject to investigation of the origin of these characteristics. Expression and localisation of plant CYP51 in different tissues would be investigated.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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