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Analysis of HexA; a new global repressor in bacterial pathogens of plants and animals
Reference
P08495
Principal Investigator / Supervisor
Professor George Salmond
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
182,880
Status
Completed
Type
Research Grant
Start date
29/09/1997
End date
29/09/2000
Duration
36 months
Abstract
The HexA gene product of the plant pathogen, Erwinia carotovora, is an important global regulator of multiple phenotypes, including virulence, but it also has pronounced pleiotropic repression effects in other organisms. We will investigate how HexA is regulated and how it acts. We will (i) analyse HexA binding to target genes from different hosts to define the target binding sequence(s); (ii) identify new genes (and functions) which come under HexA- mediated regulation; (iii) assess HexA-responsive genes for a hierarchy of responsiveness; (iv) investigate the relationship between HexA, RsmA, mRNA stability and quorum 'sensing' pheromone production, and (v) analyse regulation of HexA production.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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