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Function of the tomato GCD10-related protein in the tomato mosaic virus RNA replicase complex
Reference
P08338
Principal Investigator / Supervisor
Professor Kenneth Buck
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
206,129
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
30/09/2001
Duration
48 months
Abstract
The tomato mosaic virus (TMV-L) RNA replicase contains three essential proteins, the virus- encoded 126 kDa and 183 kDa proteins and a host protein, recently identified as the tomato analogue of the yeast GCD10 RNA-binding subunit of the translational initiation factor eIF-3. The function of the tomato GCD10-related protein, its interactions with RNA and the virus- encoded proteins in the replicase complex, and the protein and RNA domains involved in template recognition and primer, product and substrate binding, will be investigated. The hypothesis that the tomato GCD10-related protein acts an an anchor for binding of the virus- encoded replication proteins to the RNA promoter in the assembly of the replicase complex will be tested.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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