Award details

Transcription regulation by FNR and FNR like proteins

Reference	P08299
Principal Investigator / Supervisor	Professor J Green
Co-Investigators / Co-Supervisors	Professor J Guest
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	142,662
Status	Completed
Type	Research Grant
Start date	01/04/1998
End date	01/04/2001
Duration	36 months

Abstract

The FNR protein of E. coli is a global transcription regulator activating and repressing target genes in response to anaerobiosis [1]. The FNR proteins of a number of microorganisms are suspected of being involved in regulating the production of virulence factors [1]. The aim of this proposal is to: (i) to investigate the role of FNR in virulence and to establish whether fnr mutations in benign strains of E. coli are a potential source of pathogenic strains; (ii) to establish whether FNR-dependent virulence factors of E. coli and A. pleuropneumoniae are expressed from Class I promoters; (iii) to investigate the regulation of the yf1D and hlyE genes and characterise their respective products; (iv) to purify and characterise the yieL gene product, define its signal transduction pathway and identify members of its regulon.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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