Award details

Analysis and exploitation of genes for type b lantibiotic biosynthesis

Reference	P08242
Principal Investigator / Supervisor	Professor Mervyn Bibb
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	146,592
Status	Completed
Type	Research Grant
Start date	02/02/1998
End date	02/02/2001
Duration	36 months

Abstract

Type B lantibiotics are small peptides containing modified amino acids that exhibit a range of interesting properties that could lead to their development as important new pharmaceutical agents. However, they exist in only a few natural forms. We intend to exploit their biosynthetic genes to produce a range of new products. The genes for production of the Type B lantibiotic cinnamycin made by Streptomyces longisporoflavus will be cloned and genetically manipulated to produce novel compounds in the industrially-favoured Streptomyces lividans. The regulation of cinnamycin production will be studied in S. longisporoflavus and the genetically-well studied Streptomyces coelicolor, allowing knowledge-based approaches to yield improvement. (Joint with grant 218/P08244).

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

P08244 Analysis and exploitation of genes for type b lantibiotic biosynthesis

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