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Analysis of a new type 1 secretion machinery regulating Erwinia carotovora pathogenicity

Reference	P07895
Principal Investigator / Supervisor	Professor George Salmond
Co-Investigators / Co-Supervisors
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	185,809
Status	Completed
Type	Research Grant
Start date	28/04/1997
End date	28/04/2000
Duration	36 months

Abstract

We have defined a new cluster of genes in Erwinia carotovora involved in the global regulation of pathogenesis. Some of the genes in this new cluster appear to encode a novel Type 1 protein secretion system and defects in this system enhance the plant aggression of the pathogen. We aim to (1) investigate the function of all of the genes in this new cluster, (2) make defined mutants by marker exchange and assess their cell surface properties, protein targeting profiles and exoenzyme regulation effects, (3) investigate the mechanism of signal transduction from the secretion impairment to virulence up-regulation, and (4) search for, and characterise, the gene(s) encoding the regulatory protein(s) targeted through the new Type 1 secretion pathway.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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