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Saponin-detoxifying enzymes of phytopathogenic fungi as targets for disease control
Reference
P07880
Principal Investigator / Supervisor
Professor Anne Osbourn
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Sainsbury Laboratory
Funding type
Research
Value (£)
159,646
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/04/2001
Duration
42 months
Abstract
The general importance of plant saponins as preformed resistance factors and of saponin- detoxifying enzymes as fungal pathogenicity factors (already shown for the Gaeumannomyces/oat pathosystem) will be tested by production and pathogenicity testing of saponinase-deficient mutants of two unrelated fungi (Septoria lycopersici/tomato and S. avenae/oat). Inhibitors of the enzymes will be sought by screening phage display libraries of antibody fragments and random peptides, and chemical libraries, and known inhibitors of glycosyl hydrolases. The spectrum of activity of the inhibitors will be studied. Suitable examples will be applied to or introduced into plants and tested for effects of fungal infection; this could give leads to novel disease controls.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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