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Functional analysis of a novel disease resistance signalling gene EDS1 in Arabidopsis

Reference	P07874
Principal Investigator / Supervisor	Professor Jane Parker
Co-Investigators / Co-Supervisors	Professor Michael Daniels
Institution	University of East Anglia
Department	Sainsbury Laboratory
Funding type	Research
Value (£)	175,160
Status	Completed
Type	Research Grant
Start date	02/06/1997
End date	02/06/2000
Duration	36 months

Abstract

A novel disease resistance signalling gene, EDS1, has been cloned in the model plant, Arabidopsis. It is required for resistance to an oomycete pathogen, Peronospora parasitica, mediated by several different RPP genes, and for another gene, RPS4, conferring resistance to a bacterial pathogen, Pseudomonas syringae. EDS1 also contributes to resistance to P. parasitica isolates that normally only infect Brassica plants. The project proposes a functional analysis of EDS1 with respect to its sequence, expression pattern, activity, and molecular interaction with already cloned resistance gene products, including RPP5, which is known to be EDS1-dependent. An interaction trap cloning strategy will be employed to isolate other proteins that bind to EDS1 and will be complemented by a genetic screen for additional mutations in the EDSI-signalling pathway.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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