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Analysis of COII an Arabidopsis gene with homology to hnRNPS which controls defence signalling and male sterility
Reference
P07802
Principal Investigator / Supervisor
Professor John Turner
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
199,688
Status
Completed
Type
Research Grant
Start date
27/06/1997
End date
27/06/2000
Duration
36 months
Abstract
We have used a map-based cloning strategy to isolate from Arabidopsis a gene named COII. Mutations in COII produce male sterile plants which are insensitive to jasmonates, and fail to express specific wound-induced defence genes. Remarkably, the predicted COII product is a heteronuclear ribonucleotide binding protein (hnRNP), on the basis of its homology to human hnRNP (C1/C2). This indicates that COII regulates post-translational modification of pre- mRNAs, and provides the first example in plants for post-transcriptional regulation of specific gene expression. To investigate this, I propose here a genetic and biochemical study of functional domains of the COII gene, and to characterise components of the signal transduction pathway interacting with the COII product. To explore commercial opportunities, we shall also examine for homologues of COII in other species, and examine the feasibility of making male sterile plants by reverse genetics.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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