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Ubiquinone biosynthesis in Escherichia coli: regulation functions and role in cell-cell communication
Reference
P07744
Principal Investigator / Supervisor
Professor Robert K Poole
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
170,125
Status
Completed
Type
Research Grant
Start date
01/09/1997
End date
17/09/2000
Duration
37 months
Abstract
Ubiquinone (UQ) plays indispensable roles in biological electron transfer in plants, animals and microbes. In addition, UQ is important both as a source of toxic free radicals and as an antioxidant in eukaryotes, but these aspects are not understood in bacteria. This proposal seeks to determine how ubi genes specifying UQ synthesis in Escherichia coli are regulated and whether the resulting changes in UQ levels influence the kinetics of aerobic respiration. Interactions between UQ, cytochromes of the respiratory chain, and UQ reductases will be explored and the role of UQ in oxidative stress assessed. We hope to understand the significance and basis of a novel ubi-dependent example of cell-cell communication.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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