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Comparative studies on the regulation of amino acid biosynthesis in streptomycetes
Reference
P07394
Principal Investigator / Supervisor
Professor S Baumberg
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Human Biology
Funding type
Research
Value (£)
174,308
Status
Completed
Type
Research Grant
Start date
01/11/1996
End date
01/11/1999
Duration
36 months
Abstract
Amino acids (aa's) are frequent secondary metabolite precursors in streptomycetes; understanding the regulation of their metabolism is essential for manipulation of product yield. We have demonstrated in S. coelicolor physiological controls of branched chain aa biosynthesis, sequence data suggesting an attenuation mechanism. We propose: in this system (1) to test for attenuation; (2) to compare the physiology and genetics of regulation in S. coelicolor with other streptomycetes, notably S. fradiae whose physiological control differs; in appropriate systems (3) to starve for a required amino acid to check pathways where regulation was not found earlier; (4) to look for controls at the level of enzyme activity; and (5) to estimate aa pools.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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