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Nitrogen metabolite signalling in Aspergillus nidulans

Reference	P06750
Principal Investigator / Supervisor	Professor Mark Caddick
Co-Investigators / Co-Supervisors	Dr Meriel Jones
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	201,030
Status	Completed
Type	Research Grant
Start date	25/11/1996
End date	15/02/2000
Duration	39 months

Abstract

The level of available nitrogen is critical to a wide range of biological processes. In the filamentous fungus Aspergillus nidulans the principal regulatory protein involved in monitoring nitrogen levels is AREA. Closely related regulatory proteins have been characterised in a variety of other fungi, and more distantly related GATA factors have been found throughout eukaryotes. The level of available nitrogen precisely regulates AREA activity. We have recently determined that fidelity of this process is dependent on two signal transduction pathways one of which acts directly at the level of the protein and the second by modulating the stability of the areA transcript. This project aims to exploit our current understanding in order to characterise the signalling mechanisms, utilising both genetic and molecular techniques.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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