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The influence of host proteins on the expression of the herpes simplex virus immediate-early genes in sensory neurons

Reference	P06689
Principal Investigator / Supervisor	Professor Karen Lillycrop
Co-Investigators / Co-Supervisors
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	159,333
Status	Completed
Type	Research Grant
Start date	02/04/1997
End date	02/04/2000
Duration	36 months

Abstract

The molecular basis of herpes simplex virus (HSV) latency is poorly understood. Studies using a sensory neuron-derived cell line have suggested that a neuronally expressed transcription factor OCT2.5 plays a key role in the establishment and maintenance of HSV latency. In the cell line, the applicant has shown that OCT2.5 inhibits the expression of the regulatory immediate early (IE) genes, thus blocking the lytic life cycle of HSV in these cells. The aim of this project is to extend these studies and to determine whether, in the sensory neurons of the trigeminal and spinal ganglia, the major sites of HSV infection in vivo, HSV latency is due to the inhibition of IE gene expression by OCT2.5, and to investigate the role OCT2.5 plays in HSV reactivation.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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