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Identifying the components of the alpha-amanitin resistant RNA polymerase induced in baculovirus-infected cells

Reference	P06150
Principal Investigator / Supervisor	Professor Linda King
Co-Investigators / Co-Supervisors	Professor Robert Possee
Institution	Oxford Brookes University
Department	Faculty of Health and Life Sciences
Funding type	Research
Value (£)	134,448
Status	Completed
Type	Research Grant
Start date	19/08/1996
End date	05/01/2000
Duration	41 months

Abstract

The composition of the alpha-amanitin-resistant RNA polymerase induced in baculovirus-infected cells will be determined. A combination of approaches are envisaged. These include direct sequencing of isolated polymerase subunits and the use of polyclonal antibodies raised to synthetic peptide sequences to identify putative polymerase components. A further novel approach will involve the addition of epitope coding sequences to putative virus polymerase genes, which can be detected using monoclonal antibodies. Evolutionary relationships of the baculovirus RNA polymerase with other enzymes will also be determined.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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