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Analysis of the KdgR virulence regulator of the bacterial soft rot pathogen Erwinia carotovora

Reference	P06134
Principal Investigator / Supervisor	Professor George Salmond
Co-Investigators / Co-Supervisors
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	156,366
Status	Completed
Type	Research Grant
Start date	15/07/1996
End date	14/07/1999
Duration	36 months

Abstract

The KdgR protein of Erwinia carotovora (Ecc) shows low homology with KdgR of the related plant pathogen, Erwinia chrysanthemi (Echr). In Echr, KdgR is an important repressor of many genes involved in virulence and the catabolism of plant pectin. However, the Ecc protein does not act in a similar fashion but may act as an activator rather than a repressor. It may also act as an autoregulatory protein. We will: 1) Overproduce the Ecc KdgR protein in expression systems; 2) Study the interaction of Ecc KdgR with promoter regions of Ecc and Echr virulence genes and investigate the interaction of Echr KdgR with corresponding Ecc genes; 4) Investigate Ecc KdgR as a possible autoregulator and study its relationship to known global regulatory virulence genes of Ecc, and 5) Analyse the structure-function relationships of Ecc/Echr KdgR hybrids.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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