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Regulation of gene expression by ambient pH in Aspergillus nidulans with particular emphasis on acid-expressed genes
Reference
P05893
Principal Investigator / Supervisor
Emeritus Professor Herbert Arst
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
264,912
Status
Completed
Type
Research Grant
Start date
01/04/1996
End date
01/04/1999
Duration
36 months
Abstract
Previous work established that the PacC zinc finger transcription factor of Aspergillus nidulans activates expression of genes expressed predominantly at alkaline pH and prevents expression of genes expressed predominantly at acid pH. Although it is clear that PacC activates expression of alkaline-expressed genes directly, it has not been established how it prevents expression of acid-expressed genes. This proposal aims to determine whether PacC can act as a direct repressor either alone or in combination with an additional gene product or whether it acts indirectly by activating expression of a gene encoding a repressor. Additionally it seeks to uncouple the positive and negative regulatory actions of PacC by mutation.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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