Award details

Preliminary structural studies of proteins involved in phytoretroviral transmission and replication

Reference	P05885
Principal Investigator / Supervisor	Professor Andrew Hemmings
Co-Investigators / Co-Supervisors
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	126,740
Status	Completed
Type	Research Grant
Start date	22/07/1996
End date	31/10/1999
Duration	42 months

Abstract

Through an understanding of the 3-D structures of viral proteins and of their packing in viral particles, we can begin to consider strategies with which to interrupt virus propagation in infected plants. Our objective is to design novel antiviral proteins for expression in transgenic rice plants based on the crystal structures of proteins involved in Rice Dwarf Virus transmission and replication. To this end, funding for a research assistant at the RA1B level and limited equipment is requested who will perform initial purification, crystallisation and X-ray characterisation of a number of viral proteins. Full structure solution of a capsid protein may be possible within the grant period but it is intended that subsequent proposals will build on this work to solve individual structures and pursue antiviral design studies.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search