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The ambient pH signal transduction pathway in Aspergillus nidulans
Reference
P05554
Principal Investigator / Supervisor
Emeritus Professor Herbert Arst
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
67,091
Status
Completed
Type
Research Grant
Start date
01/04/1996
End date
01/03/1998
Duration
23 months
Abstract
Previous work established that the N-terminal ~40% of the PacC transcription factor of the fungus Aspergillus nidulans mediates pH regulation of gene expression, activating expression of genes expressed predominantly at alkaline pH and preventing expression of genes expressed predominantly at acid pH. This proposal aims to complete the molecular characterisation of the six pal genes of the ambient pH signal transduction pathway whose action is necessary for conversion of PacC to its functional form and one of which we have shown to encode a cysteine protease. A secondary goal is mutational identification of the protease responsible for the final step of PacC processing.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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