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The flavohaemoglobin (HMP) of Escherichia coli and its role in responses to oxidative stress and nitrogen compounds
Reference
P05184
Principal Investigator / Supervisor
Professor Robert K Poole
Co-Investigators /
Co-Supervisors
Professor M Hughes
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
198,352
Status
Completed
Type
Research Grant
Start date
01/03/1996
End date
07/12/1999
Duration
46 months
Abstract
Many microorganisms synthesise globin-like proteins of unknown function. We aim to combine molecular genetic and bioinorganic approaches to study the function of the Escherichia coli flavohaemoglobin (HMP) in relation to oxidative stress and the presence of nitrogen compounds including nitric oxide and the nitrosonium, nitroxyl and peroxynitrite ions. The mechanism(s) responsible for induction of HMP synthesis in response to superoxide (O2-) and nitrogen compounds, and the possible contribution of HMP to combating oxidative stress, will be studied. The role of HMP in regulating transcription of genes under the control of SOXR/SOXS, FNR and FUR will be examined.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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