Award details

The relationship between motility and virulence in the blackleg pathogen Erwinia carotovora subspecies atroseptica

Reference	P03960
Principal Investigator / Supervisor	Professor George Salmond
Co-Investigators / Co-Supervisors
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	158,320
Status	Completed
Type	Research Grant
Start date	08/09/1995
End date	08/10/1998
Duration	37 months

Abstract

This project involves the molecular analysis of reduced virulence mutants of the potato blackleg bacterial pathogen Erwinia carotovora (Eca). We will analyse highly pleiotropic Tn5- insertion mutants affected in motility, exoenzyme production, virulence, phage sensitivity, sensitivity to surface active agents and exhibiting alterations in outer membrane proteins. One of these mutants has a Tn5 insertion in the master regulatory gene (f1hD) for the control of the flagellar regulon containing over 40 genes arranged in a hierarchy of regulated expression. By use of gene fusions, exoenzyme activity, immunoassay and mRNA, we will investigate the relationship between motility and virulence.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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