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Biochemical properties of the soluble fumarate reductase, flavocytochrome C, from Shewanella putrefaciens

Reference	P03114
Principal Investigator / Supervisor	Professor Graeme Reid
Co-Investigators / Co-Supervisors	Professor Stephen Chapman, Dr F Ward
Institution	University of Edinburgh
Department	Inst of Cell and Molecular Biology
Funding type	Research
Value (£)	160,857
Status	Completed
Type	Research Grant
Start date	01/04/1994
End date	01/04/1997
Duration	36 months

Abstract

We shall carry out a biochemical study of flavocytochrome c from Shewanella putrefaciens. This enzyme is a soluble fumarate reductase that we shall use as an excellent model system for the membrane-bound fumarate reductases and succinate dehydrogenases from other bacteria and from eukaryotes. We aim (1) to characterise the catalytic properties of flavocytochrome c; (2) to determine its relationship to other respiratory electron carriers; and (3) to initiate a protein engineering studies to analyse the architecture of the active site. To enable this work we shall develop expression systems for altered forms of flavocytochrome c.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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