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Genetic engineering of polyketide antibiotic biosynthesis in actinomycetes
Reference
P02778
Principal Investigator / Supervisor
Professor Peter Leadlay
Co-Investigators /
Co-Supervisors
Professor James Staunton
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
796,767
Status
Completed
Type
Research Grant
Start date
01/06/1994
End date
30/09/1997
Duration
41 months
Abstract
1. The production of novel polyketide metabolites by systematic genetic engineering of the genes for type 1 polyketide synthases. 2. Investigation of the role of newly-discovered activator genes in increasing levels both of polyketide synthases and of antibiotic production. 3. Study of the role of post-translational modification in controlling the activity of type 1 polyketide synthases.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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