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Role of malic enzyme in fatty acid desaturation and related activities in filamentous moulds
Reference
P02767
Principal Investigator / Supervisor
Professor Colin Ratledge
Co-Investigators /
Co-Supervisors
Institution
University of Hull
Department
Academic Division of Medicine
Funding type
Research
Value (£)
114,259
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
01/10/1997
Duration
36 months
Abstract
The organism of study will be principally Mucor circinelloides. The role of a microsomal malic enzyme (ME) in fatty acid desaturation and its possible linkage via cytochrome b5 to the desaturase(s) will be studied. The mode of action of flavanones that appear to be specific inhibitors of ME will be investigated. A mutation programme will be developed in which mutants with altered ME activities will be obtained. The biochemical consequences of ME negative and ME overproducing mutants to be examined for increases in polyunsaturated fatty acid formation, especially from exogenous fatty acids.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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