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Control of plant cell division in tissue culture and transgenic plants
Reference
P01552
Principal Investigator / Supervisor
Professor James Murray
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
School of Clinical Medicine
Funding type
Research
Value (£)
146,978
Status
Completed
Type
Research Grant
Start date
01/11/1994
End date
31/01/1998
Duration
41 months
Abstract
In mammals, G1 cyclins, (cyclins D and E) are involved in the response of cells to growth factors and in their commitment to cell division. We have isolated the first plant G1 cyclins. Three groups of cDNAs were cloned from Arabidopsis using a functional assay. The amino acid sequence of all three suggests they are direct equivalents of mammalian D-type cyclins. The genes we have cloned are therefore likely to act as the missing link between plant growth regulators and cell division. We propose to analyse the role of these novel cyclins in (1) controlling cell growth in rapidly growing cultures, (2) the response of quiescent cells to plant growth regulators, and (3) establishing patterns of growth and differentiation in transgenic plants.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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