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Gene expression profiling in Drosophila and mouse brain: Defining the molecular phenotype and mechanisms regulating alcohol-induced behaviour
Reference
NEU15438
Principal Investigator / Supervisor
Dr Lynne Mayne
Co-Investigators /
Co-Supervisors
Dr Jane Davies
,
Professor David Stephens
Institution
University of Sussex
Department
Sch of Education and Social Work
Funding type
Research
Value (£)
480,552
Status
Completed
Type
Research Grant
Start date
01/06/2001
End date
08/10/2004
Duration
40 months
Abstract
The long-term aim of our work is to understand the molecular mechanisms that regulate behaviour in response to drugs of abuse. This application sets out to define global changes in gene expression that occur in the brain in response to acute and chronic alcohol exposure and to relate these changes to alcohol-induced behaviour. DNA microarray technology will be used to profile gene expression in both Drosophila and mouse, to reveal patterns of gene expression conserved between the two species, which are predicted to represent fundamental pathways in the response to alcohol. Genetic manipulation of selected genes in Drosophila will test the importance of these pathways in regulating alcohol-induced behaviour.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Neurone (NEU) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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