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Non-image forming photoreceptive pathways in the mammalian retina: A genomic cellular and systems approach

Reference	NEU15432
Principal Investigator / Supervisor	Professor Russell Foster
Co-Investigators / Co-Supervisors	Professor Mark Hankins, Professor Robert Lucas
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	429,632
Status	Completed
Type	Research Grant
Start date	27/07/2001
End date	26/07/2004
Duration	36 months

Abstract

In addition to the classical rod/cone mediated visual pathway, recent data demonstrate that the mammalian retina includes independent photosensitive pathways involved in quantifying environmental irradiance. We describe an integrated series of experiments designed to investigate this pathway at molecular, cellular and functional (whole animal) levels. The studies address a series of coherent questions designed to elucidate the mechanisms of non-image forming photoreceptive pathways and place them within a functional context: (1) What is the cellular basis of this non-image forming photoreceptive pathway? (2) What are the dynamics of its light response? (3) What phototransduction mechanisms translate photon absorption into a neural signal in these photoreceptors? (4) How does this novel photoreceptor interact with rod and cone pathways.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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