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Neurophysiological correlates and effects on gene expression of the defect in the calcium channel alpha2delta2 subunit

Reference	NEU15421
Principal Investigator / Supervisor	Professor Annette Dolphin
Co-Investigators / Co-Supervisors	Dr Michele Rees
Institution	University College London
Department	Neuroscience Physiology and Pharmacology
Funding type	Research
Value (£)	419,244
Status	Completed
Type	Research Grant
Start date	09/07/2001
End date	08/05/2005
Duration	46 months

Abstract

By combining the skills of 3 laboratories in electrophysiology, genetics and imaging, the function of a specific calcium channel subunit, alpha2delta-2, will be studied and its role in synaptic transmission established. This subunit is particularly strongly expressed in Purkinje cells in the cerebellum and in the habenula and septal nuclei. In du-2J mice a mutation in the gene for this subunit results in loss of the full length protein. The effect of the mutation on expression of other genes will be examined. The precise effect of the mutation on expression, kinetics and conductance of VGCC and on synaptic transmission will be studied.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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