Award details

GluR2 and molecular mechanisms of synaptic plasticity at individual synapses in the hippocampus

Reference	NEU15416
Principal Investigator / Supervisor	Professor Mike Stewart
Co-Investigators / Co-Supervisors	Professor Ralf Schoepfer
Institution	Open University
Department	Life, Health & Chemical Sciences
Funding type	Research
Value (£)	447,680
Status	Completed
Type	Research Grant
Start date	08/10/2001
End date	01/04/2005
Duration	42 months

Abstract

Detection of synaptically-evoked calcium transients in dendritic spines permits monitoring activation and plasticity of individual synapses in hippocampal slice preparations, in turn allowing detection and optical quantal analysis of LTP at these synapses. We will now exploit this approach to identify the structural and molecular basis of plasticity at the individual potentiated synapses. We will examine hypotheses regarding mechanisms of expression of LTP, namely, that the increase in synaptic strength is a consequence of synaptic insertion or redistribution of specific molecules such as GluR2, and/or structural modifications including addition of new presynaptic release sites or splitting of spines.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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