Award details

Molecular mechanisms and functional roles of acid-sensing ion channels

Reference	NEU15411
Principal Investigator / Supervisor	Professor Peter Anthony McNaughton
Co-Investigators / Co-Supervisors	Professor Stephen McMahon
Institution	University of Cambridge
Department	Pharmacology
Funding type	Research
Value (£)	194,928
Status	Completed
Type	Research Grant
Start date	01/01/2002
End date	01/01/2005
Duration	36 months

Abstract

The detection of extracellular pH is fundamental for many neuronal functions, but our knowledge of the underlying transduction mechanisms is quite limited. Molecular cloning has recently identified a group of so-called Acid Sensing Ion Channels (ASICs). We will examine the mechanisms of acid detection in one model system - primary sensory nociceptors, and the contribution played by the different ASICs. We will use this information to assess in animals and humans the functional importance of different ASICs for pain appreciation. The combined expertise of the two applicants' laboratories will permit an analysis that is not possible in either alone. (Joint with grant 29/NEU15412).

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

NEU15412 Molecular mechanisms and functional roles of acid-sensing ion channels

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