Award details

Role of integrins in sensory nerve regeneration

Reference	NEU15400
Principal Investigator / Supervisor	Professor Charles Streuli
Co-Investigators / Co-Supervisors	Professor Paul Fernyhough, Professor David Tomlinson
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	182,292
Status	Completed
Type	Research Grant
Start date	01/04/2002
End date	01/04/2005
Duration	36 months

Abstract

Axonal regeneration in the adult peripheral nervous system (PNS) after injury or in disease requires neurotrophins and adhesion to extracellular matrix. Integrins potentiate growth factor signals, but mechanism of crosstalk with neurotrophin receptors in neurones is not known. We will use genetic and immunological techniques to identify which integrins are required for nerve regeneration in vivo and in culture. Protein analysis and imaging techniques will be used to determine if integrin synergy with neurotrophins occurs through crosstalk of downstream signalling pathways and/or spatial proximity of respective receptors. The results will form a theoretical framework for novel therapies to reverse sensory loss in neurodegenerative diseases of the PNS.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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