Award details

Neuronal plasticity in a vertebrate neuroendocrine system

Reference	NEU15399
Principal Investigator / Supervisor	Professor Catherine McCrohan
Co-Investigators / Co-Supervisors	Professor Richard Balment, Dr Matthew Brierley, Professor Daniela Riccardi
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	398,016
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	01/10/2004
Duration	36 months

Abstract

The project will define the molecular and cellular mechanisms underpinning neuronal plasticity in neuroendocrine systems. To obviate problems experienced with systems embedded in the brain the uniquely accessible caudal neurosecretory system (CNSS) of teleost fish has been chosen for this study. Plasticity of the CNSS Dahlgren cells associated with adaptation to marine or fresh water media will be characterised at the levels of electrical activity, neurosecretion, and mRNA and protein expression of ion channels and neuromodulatory receptors. The hypothesis that cortisol and prolactin play a key role in triggering the functional transition of Dahlgren cells between their fresh and sea water states will be tested.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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