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The role of Rho GTPases in axonal regeneration in the central nervous system

Reference	NEU15397
Principal Investigator / Supervisor	Dr john pizzey
Co-Investigators / Co-Supervisors	Professor Martin Berry, Dr David Alan Tonge
Institution	King's College London
Department	Reproductive Health Endocrinology Dev
Funding type	Research
Value (£)	173,080
Status	Completed
Type	Research Grant
Start date	12/11/2001
End date	31/12/2004
Duration	38 months

Abstract

Axons of the central nervous system (CNS) generally fail to regenerate in adult mammals. However, recent work has shown that inhibition of Rho GTPases by the C3 enzyme of botulinum toxin can promote axonal regeneration in the optic nerve and spinal cord. In this project, we plan to use a replication-deficient HSV-1 vector to infect CNS neurones with cDNAs encoding genes whose expression may be expected to promote axonal regeneration by interfering with Rho signalling. In addition we will also use the vector to deliver cDNA encoding alpha7 integrin since this may act upstream of the Rho signalling pathway and its expression is strongly correlated with successful axonal regeneration in the peripheral nervous systems.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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