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Magnetic resonace imaging of virally-mediated gene delivery to the intact brain and its functional consequences
Reference
NEU15394
Principal Investigator / Supervisor
Professor David Latchman
Co-Investigators /
Co-Supervisors
Professor David Gadian
Institution
University College London
Department
Institute of Child Health
Funding type
Research
Value (£)
189,164
Status
Completed
Type
Research Grant
Start date
01/03/2002
End date
30/04/2006
Duration
50 months
Abstract
In the post-genomics era there is a need to characterise the functional effects of specific genes at the whole animal level. Virally-mediated gene delivery offers the advantage that it can be used to analyse the effects of a gene after as well as before an insult. We have developed Herpes simplex virus (HSV) vectors which can safely and efficiently deliver genes to the brain. However, analysis of gene expression or functional effects requires sacrifice of the animal. We will use MRI to (1) examine the pattern of beta-galactosidase reporter gene expression following viral inoculation in a non-invasive manner and (2) analyse the functional effects of the viruses over-expressing individual heat shock proteins in stroke models.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Neurone (NEU) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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