Award details

Phenotypic profiling of energy-sensing neurones

Reference	NEU15392
Principal Investigator / Supervisor	Professor Simon Luckman
Co-Investigators / Co-Supervisors	Dr Leonard Best, Dr Gerard Brady, Professor Hugh Piggins
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	408,356
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	01/05/2006
Duration	55 months

Abstract

Our understanding of how neurones integrate different metabolic signals is superficial, though much can be learned from non-neuronal cells that have similar energy-sensing abilities, such as pancreatic islet cells. State-of-the-art electrophysiological and molecular techniques will be coupled to determine the roles of known signallers, such as a different leptin receptor forms and the K atp channel, as well as more novel players, such as glucose-sensitive anion channel and malonyl-CoA. Analogues with non-neural cells may prove particularly useful in determining specific differences between anabolic and catabolic neurones. This information will allow us to determine how the signalling pathways are compromised in states of energy imbalance.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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