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Correlation of gene expression and behaviour in transgenic animal models
Reference
NEU15388
Principal Investigator / Supervisor
Professor Stephen Dunnett
Co-Investigators /
Co-Supervisors
Professor Sir Martin Evans
,
Professor Lesley Jones
,
Professor Michael Krawczak
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
619,684
Status
Completed
Type
Research Grant
Start date
01/04/2002
End date
02/09/2005
Duration
41 months
Abstract
Several transgenic models expressing expanded glutamine tracts are now available, of which many (but not all) display neurodegenerative phenotypes. We will analyse representative strains of transgenic mice using an integrated approach relating behaviour to global gene expression. Relevant strains are either available in Cardiff or being imported as part of our current projects. Affymetrix GeneChips and cDNA arrays will be used to analyse gene expression. Behavioural analysis will include both neurological screening and more complex sensorimotor and cognitive evaluation. The multidimensional nature of the data requires development of specific methods for analysis of gene expression- functional interactions on large sets. This project will allow for the identification of both known and unknown genes regulating different aspects of neuropathology and behaviour.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Neurone (NEU) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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