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Molecular cellular and functional studies of oscillations in the hippocampus
Reference
NEU15387
Principal Investigator / Supervisor
Professor Karl Giese
Co-Investigators /
Co-Supervisors
Dr Roussudan Bourtchouladze
,
Professor John O'Keefe
Institution
University College London
Department
The Wolfson Inst for Biomedical Research
Funding type
Research
Value (£)
509,384
Status
Completed
Type
Research Grant
Start date
15/09/2001
End date
15/09/2004
Duration
36 months
Abstract
The hippocampus is an essential brain structure for spatial and episodic learning and memory (L and M), and its oscillations are thought to be important for cognitive function. We propose to study the molecular and cellular basis of hippocampal oscillations and their functional significance, using molecular genetics. Based on carbachol effects, we will manipulate the modulation of three potassium channel subunits (Kv3.4, Kv4.2 and Kv4.3) and we will analyse these mutants together with two existing mutants (CaMKII-T286A, KvBeta1.1-KO). We will study changes in place cell field sizes and shapes, modifications in EEG theta oscillations and spatial L and M. The analyses will reveal mechanisms underlying hippocampal oscillations and their role in L and M.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Neurone (NEU) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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