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Award details
Development of canine adenovirus as a human gene therapy vector and as a vaccine vector
Reference
MOL04737
Principal Investigator / Supervisor
Dr Lesley Nicolson
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Veterinary School
Funding type
Research
Value (£)
148,152
Status
Completed
Type
Research Grant
Start date
01/10/1995
End date
01/10/1998
Duration
36 months
Abstract
The aim of this project is to lay the groundwork for development of CAV as a human gene therapy vector and as a vaccine vector for domestic animals. Complete sequence analysis of the CAV genome will be undertaken providing invaluable data for the cloning and manipulation of CAV DNA. Deletions will be introduced into the E3, E1 and E2a transcriptional regions of the CAV genome and E1 and E2a complement cell lines produced. Recombinant viruses will be generated using complementing cell lines where appropriate.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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