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Exploring and refining our concept of the nicotinic pharmacophore
Reference
MOL04724
Principal Investigator / Supervisor
Professor Timothy Gallagher
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Chemistry
Funding type
Research
Value (£)
77,158
Status
Completed
Type
Research Grant
Start date
01/12/1995
End date
01/06/1998
Duration
30 months
Abstract
As a mechanism for rationalising drug design and function, the classical nicotinic pharmacophore remains poorly defined. Major shortcomings become apparent when the model is applied to the newer generations of potent ligands now available. The pharmacophore needs refinement - the impetus being the obvious clinical potential of nicotinic ligands - and this will be addressed by considering the structural and enantiomeric relationships existing between ligands; enantiospecificity is not accommodated by current models. Applying our results to designing new, synthetic ligands will provide new molecular probes and further refine the pharmacophore model.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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