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Activation of antibiotic biosynthetic pathways in Streptomyces by a novel family of regulatory proteins
Reference
MOL04653
Principal Investigator / Supervisor
Professor Mervyn Bibb
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
135,283
Status
Completed
Type
Research Grant
Start date
01/08/1996
End date
21/08/1999
Duration
37 months
Abstract
Antibiotic production in streptomycetes is subject to complex regulation by genes that act pleiotropically and in a pathway-specific manner. The molecular basis for the action of these regulators is not understood. We aim to remedy this deficiency by using molecular genetics to analyse the pathway-specific regulatory genes for production of two antibiotics in Streptomyces coelicolor, and their interaction with a putative pleiotropic regulatory gene, afsR. The products of these genes constitute a novel family of proteins with relatives active in other antibiotic pathways. Understanding their mechanism of action will expand our fundamental knowledge of the structure and function of regulatory proteins and in the long- term will be of value in improving the yield of antibiotic fermentations.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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