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Manipulation of plant chromosomes in vivo: towards the construction of plant artificial chromosomes
Reference
MOL04648
Principal Investigator / Supervisor
Professor James Murray
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Institute of Biotechnology
Funding type
Research
Value (£)
158,104
Status
Completed
Type
Research Grant
Start date
01/12/1995
End date
01/12/1998
Duration
36 months
Abstract
The construction of artificial chromosomes in plants would open up new areas of research in chromosome maintenance, and provide vector systems capable of carrying large quantities of DNA in transgenic plants. No currently available avenues appear practical for building such molecules. We propose a novel strategy of deleting large regions of plant chromosomes in vivo, in order to construct stable supernumerary chromosome fragments (CFs). We present strategies to produce both circular and linear CFs, and evidence from classical studies that such fragments will be maintained. Their behaviour will be analysed, and their potential as vector systems assessed.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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