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Structural and functional mapping of phospholipase C-beta isoforms using monoclonal antibodies

Reference	MOL04642
Principal Investigator / Supervisor	Professor Charles Downes
Co-Investigators / Co-Supervisors
Institution	University of Dundee
Department	College of Life Sciences
Funding type	Research
Value (£)	141,424
Status	Completed
Type	Research Grant
Start date	01/04/1996
End date	01/04/1999
Duration	36 months

Abstract

Receptor and G-protein activated phospholipase C-beta isoforms messengers, inositol trisphosphate and diacylglycerol. Recombinant PLCbetas will be used to raise panels of monoclonal antibodies which will be selected for interaction at G-protein, substrate and interfacial recognition sites. Epitope mapping approaches will reveal the spatial organisation and sequence relationships of these sites. In addition, these immunological tools will be used in subcellular localisation and enzyme mechanistic studies. These studies are an essential prelude to any attempt at rational design of potent inhibitors of this important group of enzymes.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Molecules (Ropa) (MOL) [1994]
Funding Scheme	X – not Funded via a specific Funding Scheme

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