Award details

Anti-cancer chemotherapy: targeting novel nucleosides and nucleotide prodrugs

ReferenceMOL04633
Principal Investigator / Supervisor Professor G Boons
Co-Investigators /
Co-Supervisors
Institution University of Birmingham
DepartmentSchool of Chemistry
Funding typeResearch
Value (£) 20,431
StatusCompleted
TypeResearch Grant
Start date 02/10/1995
End date 01/01/1999
Duration39 months

Abstract

From a chance observation, we wish to make nucleoside and nucleotide prodrugs from 5- fluorouracil and 4-thio-2-deoxyribose. The following points will be addressed : the conditions necessary for stereoselective synthesis; the synthesis of novel prodrugs of the 5'- nucleotide which are labile to chemical hydrolysis, enzymatic attack or both; the synthesis of such prodrugs carrying targeting molecules for delivery to specific locations and investigating the cellular metabolism and mode of action of these analogues. This information will then be used to feed back into the synthesis to enhance further the selectivity of these compounds.

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Molecules (Ropa) (MOL) [1994]
Funding SchemeX – not Funded via a specific Funding Scheme
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