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Conjugate chemosensors

Reference	MOL04627
Principal Investigator / Supervisor	Professor David Parker
Co-Investigators / Co-Supervisors
Institution	Durham University
Department	Chemistry
Funding type	Research
Value (£)	89,556
Status	Completed
Type	Research Grant
Start date	01/10/1995
End date	01/10/1998
Duration	36 months

Abstract

Luminescent chiral Eu and Tb complexes will be conjugated to various cyclodextrin derivatives. Switching on of the metal-based luminescence following cyclodextrin binding by intramolecular energy transfer from matched aryl substrates will allow chemoselective and enantioselective phosphorescent sensory systems to be studied. Close conjugation of the Eu/Tb complexes to known major or minor DNA groove-binders which can also function as an antenna for the metal-based luminescence may allow new phosphorescent competitive assays of DNA binding to be developed.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Molecules (Ropa) (MOL) [1994]
Funding Scheme	X – not Funded via a specific Funding Scheme

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